If you measure a knife handle with a ruler and find the exact midpoint, mark it, and then balance the knife on your finger at that mark — the knife will tip toward the blade. Every time. This is because the optical center of an object and the gravitational center of an object are rarely the same place.
This is a problem you solve in design.
The eye lies
The eye wants symmetry. The eye wants the handle to be the same length as the blade. The eye does not care about mass. When you grip a knife by its visual center, you grip it about ten millimeters toward the blade from where you should — and your wrist makes a tiny correction every time you cut. Over a thousand cuts that correction becomes fatigue.
The fix
Move the optical center to where the gravitational center actually is. You do this by tapering the handle slightly toward the butt, which makes the eye think the handle is shorter than it is, and so the hand grips farther back. The hand was always going to grip the heaviest part. The design just lets it.
The pocket knives we make have about three degrees of taper. It's not visible at a glance. You only feel it after a few minutes — as the absence of the wrist correction you didn't know you were making.